The S85 V10 did not experience a rash of early failures like the S54 due to the bearings and neither did the S65 V8 in the E9X M3 based on it. However, as the motors reach higher mileage it is becoming clear the motors suffer from unnaturally high rod bearing wear. Why is this? One reason is that the pistons and rods may be a bit too heavy for such a high revving motor (despite BMW's marketing they go with what is cheapest in modern times) causing more wear than normal. The oiling system especially in the S65 V8 is weak so track junkies have been experiencing rod bearing wear issues.
This problem is known in E9X M3 circles with the S65 V8 but it is now coming out with the S85 V10. Why later on the S85? Because the S85 has a slightly different oiling system (BMW went even cheaper on the S65 and this is why a dry sump oiling system is recommended for track guys) and because S85 owners only now are supercharging which puts more stress on the motor. There are more S65 V8's tracking and supercharged so the issue is far more well known with the V8 than with the V10.
For those doubting, here is a picture of BimmerBoost user @CV10T's rod bearings at 91k miles from his S85 V10. Not particularly pretty are they?
So what can one do to prevent premature bearing wear and even worse a motor failure? Well, frequent oil changes are recommended to remove any material in the oil. Secondly, replacing the factory bearings with a set of aftermarket bearings is a good idea. The job is not that bad as @CV10T stated replacing his bearings cost 15 hours of labor plus the cost of the bearings.
BimmerBoost vendor VAC Motorsport has several coated bearing options available including those for the S85 V10 and S65 V8.
Gentlemen, take care of this problem before it's too late especially if you do a lot of spirited driving at high RPM or have a power adder.