The Benz is 300 pounds heavier than the Caddy. So which wins? Skip to the 7:00 minute mark in the video to see the drag race and see the E63 run away from the Cadillac. We get no timeslips though and no numbers at all for this acceleration test. Just the driver making loud "Woohooo" noises as the Benz pulls away. So, the E63 is faster but we do not know by exactly how much making what should be a great and useful review just below-average.
The MotorTrend reviewer (who is somewhat annoying) in the video states he prefers the CTS-V's driving dynamics compared to the Mercedes. Both are clearly great wagons and we are happy Mercedes and Cadillac sell them in the US market. We just wish more people bought them as they are deserving of it.